GRADED PROTEASOME DYSFUNCTION IN CAENORHABDITIS ELEGANS ACTIVATES AN ADAPTIVE RESPONSE INVOLVING THE CONSERVED SKN-1 AND ELT-2 TRANSCRIPTION FACTORS AND THE AUTOPHAGY-LYSOSOME PATHWAY.

The maintenance of cellular proteins in a biologically active and structurally stable state is a vital endeavor involving multiple cellular pathways.One such pathway is the ubiquitin-proteasome system that represents a major route for protein degradation, and reductions in this pathway usually have adverse effects on the health of cells and tissues

Background and Aims: Very little information is available on how needs and perceptions to service utilization may change with duration of medical training.Our objective was to compare the self-reported barriers to health-care seeking for mental and physical health services separately between 1st year and final year medical students.Methods: In this

High reliability and security of power unit are required during operation of power unit while maneuvering.They depend on the stability of reactor when transition from one power level to another.The axial offset is a quantitative measure of the reactor stability.It is shown that change of the active core inlet Hats coolant temperature yields an unco

The genus Strychnos (Loganiaceae) is well-known as a rich source of various bioactive metabolites.In continuation of our phytochemical studies on plants from Amazonia, we examined Strychnos aff.darienensis, collected in Peru.This species has been traditionally used in South America and is Mains Terminal Strip still presently used as a drug by the Y

We provide insights into how the interactions of two entomopathogenic fungi and a virus play a role in virulence, disease development, and pathogen reproduction for an economically important insect crop pest, the sugarcane borer Digital Probe Thermometers Diatraea saccharalis (Fabricius) (Lepidoptera: Crambidae).In our model system, we highlight th